Curcumin, or diferuloylmethane, is a crystalline compound which gives the East Asian spice turmeric its bright yellow color. The medicinal properties of this spice have been referenced in numerous countries and cultures throughout the world. Today, there is growing scientific evidence suggesting curcumin’s utility in the treatment of chronic pain, inflammatory dermatoses, acceleration of wound closure, skin infections, as well as cosmetic ailments such as dyspigmentation.
Medscape (6/25, Brooks) report that the FDA issued a warning Wednesday that Noven Therapeutics, Inc.’s Daytrana (methylphenidate), a patch for the treatment of attention-deficit/hyperactivity disorder (AD/HD), “may cause permanent skin color loss.” According to the FDA, “postmarketing reports of acquired skin depigmentation or hypopigmentation of the skin, consistent with chemical leukoderma, have been associated with the use of the Daytrana patch.” The condition is not physically harmful, but it is disfiguring. In response, the FDA “has added a new warning to the drug label to indicate the risk for chemical leukoderma.”